Download E-books Pharmacophores and Pharmacophore Searches (Methods and Principles in Medicinal Chemistry, Vol. 32) PDF
This guide is the 1st to handle the sensible features of this novel approach. It offers a whole evaluate of the sector and progresses from basic issues to genuine existence eventualities in drug discovery examine. beginning with an introductory historic review, the authors circulation directly to speak about ligand-based ways, together with 3D pharmacophores and 4D QSAR, in addition to the idea that and alertness of pseudoreceptors. the following part on structure-based ways comprises pharmcophores from ligand-protein complexes, turn and 3D protein-ligand binding interactions. the entire is rounded off with an entire part dedicated to functions and examples, together with modeling of ADME houses. With its serious evaluate of pharmacophore-based suggestions, this booklet represents a worthy reduction for venture leaders and decision-makers within the pharmaceutical undefined, in addition to pharmacologists, and medicinal and chemists.
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