Download E-books Pharmacophores and Pharmacophore Searches (Methods and Principles in Medicinal Chemistry, Vol. 32) PDF

This guide is the 1st to handle the sensible features of this novel approach. It offers a whole evaluate of the sector and progresses from basic issues to genuine existence eventualities in drug discovery examine. beginning with an introductory historic review, the authors circulation directly to speak about ligand-based ways, together with 3D pharmacophores and 4D QSAR, in addition to the idea that and alertness of pseudoreceptors. the following part on structure-based ways comprises pharmcophores from ligand-protein complexes, turn and 3D protein-ligand binding interactions. the entire is rounded off with an entire part dedicated to functions and examples, together with modeling of ADME houses. With its serious evaluate of pharmacophore-based suggestions, this booklet represents a worthy reduction for venture leaders and decision-makers within the pharmaceutical undefined, in addition to pharmacologists, and medicinal and chemists.

Show description

Read Online or Download Pharmacophores and Pharmacophore Searches (Methods and Principles in Medicinal Chemistry, Vol. 32) PDF

Best Clinical Chemistry books

Enzyme Kinetics and Mechanism, Part A: Initial Rate and Inhibitor Methods, Volume 63

The severely acclaimed laboratory common, tools in Enzymology, is likely one of the such a lot hugely revered guides within the box of biochemistry. in view that 1955, every one quantity has been eagerly awaited, often consulted, and praised by way of researchers and reviewers alike. The sequence includes a lot fabric nonetheless suitable this day - really a vital ebook for researchers in all fields of existence sciences.

The Enzymes, Volume 25: Molecular Machines Involved in Protein Transport across Cellular Membranes

This quantity of The Enzymes positive factors high-caliber thematic articles relating to molecular machines interested in protein delivery throughout mobile membranes. The ebook includes 5 components which span the variety of membranes together with bacterial, endoplasmic reticulum, mitochondrial, chloroplast, and peroxismal.

Handbook of Cell Signaling, Second Edition (Cell Biology)

KEY FEATURES:* comprises over 350 chapters of finished assurance on phone signaling * contains dialogue on issues from ligand/receptor interactions to organ/organism responses* presents undemanding, well-illustrated, respected content material by means of specialists within the fieldDESCRIPTION:Handbook of telephone Signaling, Three-Volume Set, 2e, is a finished paintings overlaying all facets of intracellular sign processing, together with extra/intracellular membrane receptors, sign transduction, gene expression/translation, and cellular/organotypic sign responses.

Analysis, Synthesis, and Design of Chemical Processes (2nd Edition)

A brand new variation of this name is accessible, ISBN-10: 0135129664 ISBN-13: 9780135129661

Extra resources for Pharmacophores and Pharmacophore Searches (Methods and Principles in Medicinal Chemistry, Vol. 32)

Show sample text content

Rated 5.00 of 5 – based on 26 votes