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By A A. Johansen (auth.), B. C. Morson (eds.)

Immunology, in all its aspects of immunochemistry, humoral immunity, mobile immunity, immunodiagnosis, and immunotherapy, is at present the main quickly advancing self-discipline of medical and experimental oncology. yet as in so much constructing matters, it really is always beset with difficulties of method and nomenclature, either one of that are frequently intertwined. Indicative of this challenge are our round definitions of antigen and antibody. one other fre­ quent challenge is using the phrases "specific" and "associated" while characterizing re­ activities to tumors or the antigenic houses of neoplasms. while utilized to melanoma, those phrases are patently very based upon the equipment used to illustrate those characteristics. certainly, the very varied nature and multitude of sorts of melanoma avoid our making gen­ eralizations or express statements relating to tumor "specificity. " comparable difficulties come up whilst one considers that many antigens present in malignant tumors proportion sure homes with embryonic or fetal tissues. First, those observations emphasize a scarcity of real tumor specificity, for which cause the class of oncofetal antigens has been demonstrated. moment, even if such antigens are really oncofetal is dependent upon the strategy of detection used, and it's been came across that right here too specificity decreases because the antigen assay raises in sen­ sitivity. hence, no matter if ingredients might be really oncofetal in nature nonetheless is still an issue of dialogue, and such phrases needs to consequently be utilized in an operational sense.

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