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By Robert K. Ockner
Complicated and unexplained phenomena are inclined to foster unorthodox views. This ebook is an instance, as is a previous book that emphasised the idea that middleman metabolism may possibly play an important and picking position in hepatocyte proliferation and 1 tumorigenesis. formula of this speculation was once according to an try and make clear a number of poorly understood phenomena; together with the observations: 1) that xenobiotic peroxisome proliferators similar to the fibrate hypolipidemic brokers result in hepatocyte proliferation and carcinogenesis in rodents; 2) that benign and malignant liver tumors complicate the human syndrome of glycogen garage illness sort I (glucose-6-phosphatase deficiency); and three) that during this comparable syndrome, management of glucose exerts an anti-tumor influence. Fatty acid and glucose metabolism are tightly associated in a we- verified and profoundly inportant interaction. This connection, including the truth that peroxisome proliferator-induced hepatocyte proliferation and carcinogenesis displays inhibition of mitochondrial carnitine palmitoyltransferase-I and fatty acid oxidation, urged the prospect that law of fatty acid metabolism might turn out to be a pivotal determinant within the keep an eye on of telephone development. In 1993, the yr during which the paper stated above used to be released, perception into the significance of progress components and sign transduction pathways in mobile cycle law used to be expanding quickly, yet metabolic and vigorous features of mobile proliferation had attracted particularly little recognition. regardless of this, the concept that appeared inescapable that the 2 probably targeted and unrelated determinants ― sign transduction and metabolism ― have been integrally associated.
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